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pentobarbital will lower the extent or effect of alosetron by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Unknown.pentobarbital will minimize the level or impact of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Double brexpiprazole dose over 1-2 weeks if admin